Official Glossary

This glossary is intended to support understanding of key terminology used in the field of vascular aging. It is an evolving document which will be adapted as new concepts are identified in the field.

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P

What is it?

Pulse wave velocity (PWV) is the speed at which the arterial pulse wave propagates along an arterial segment [M. O’Rourke 2002]. PWV is a marker of vascular ageing because it is related to the stiffness and diameter of the arteries, as demonstrated by the Moens-Korteweg equation [Tijsseling 2012], which states that

PWV = sqrt(E h / D rho),

where E is the Young’s modulus of the arterial wall, h is its thickness, D is its diameter, and rho is the density of blood. Both the stiffness and diameter of major arteries (principally the aorta) change with age [Hickson 2010], resulting in an increase in pulse wave velocity [Reference Values for Arterial Stiffness’ Collaboration 2010].

Why do we measure it?Aortic PWV has been observed to be predictive of cardiovascular morbidity and mortality, independently of other risk factors [Vlachopoulos 2010, Ben-Shlomo 2014]. Individuals with ‘Early vascular aging’ (i.e., a higher PWV value than the normal value for their age) are at increased cardiovascular risk [Nilsson 2009].
How can it be measured?

Broadly, there are two approaches to measuring PWV: (i) measurement between two sites; and (ii) measurement at a single site. These are illustrated in the Figure, and now described.

Figure: Pulse wave velocity (PWV) measurement techniques: (a) between two sites using simultaneously acquired pulse waves; (b) between two sites using synchronous pulse waves gated by an ECG signal; and (c) using multiple pulse waves at a single site (Source: Charlton P.H., ‘File:Pwv measurement fig.svg’, https://commons.wikimedia.org/wiki/File:Pwv_measurement_fig.svg (accessed 26 April 2021); reproduced under CC BY 4.0.

Measurement between two sites: Two arterial pulse waves are measured, one proximal to the heart (such as at the carotid artery), and one further from the heart (such as at the femoral artery). PWV is calculated from the time delay between the pulse waves, and the difference in arterial path lengths from the heart to each measurement site.

The time delay between pulse waves can be obtained in two ways. Firstly, if the pulse waves are recorded simultaneously then the delay can be calculated as the delay between the two pulse waves. Secondly, if the pulse waves are recorded sequentially then each pulse wave must be recorded alongside a simultaneous signal from which the time of cardiac ejection can be estimated (such as the ECG), allowing the time delay between the pulse waves to be approximated as the difference in time delays between each pulse wave and its marker of cardiac ejection. A variety of algorithms can be used to extract the timing of pulse waves [Gaddum 2013], and the choice of algorithm can have a large impact on performance [Obeid 2017].

The arterial path length can be obtained by [Reusz 2020]: (i) estimating it as a proportion of the distance between measurement sites; or (ii) calculating the difference in surface distances between the heart and each measurement site.

Having obtained a time delay and arterial path length, PWV is then calculated as

PWV = length of arterial segment / pulse transit time,

where the ‘length of arterial segment’ is the arterial path length between the two sites, and the ‘pulse transit time’ (PTT) is the time delay between pulse arrival at the proximal and distal site.

Measurement at a single site:
Alternatively, local PWV can be estimated from two types of pulse wave measured at a single site (e.g. two of: blood pressure, velocity, flow rate and arterial diameter) [Alastruey 2011].

Where is it measured?PWV measurements have been obtained at several measurement sites. The gold standard for PWV measurement is between carotid and femoral sites [Van Bortel 2012], since the resulting arterial path consists mostly of the descending aorta, a principal site of vascular ageing. Several alternative pairs of sites have been used, including the radial and brachial arteries, and finger, ankle and toe sites [Laurent 2006]. Single-site measurements are often conducted at the carotid artery. The choice of measurement sites influences the extent to which PWV measurements are representative of aortic PWV [Willemet 2015].
References
  1. M. O’Rourke, et al., 2002: 10.1016/S0895-7061(01)02319-6
  2. A.S. Tijsseling, A.A. Anderson, 2012: Isebree Moens and D.J. Korteweg: On the speed of propagation of waves in elastic tubes. In Proceedings of the BHR Group – 11th International Conferences on Pressure Surges; Lisbon, Portugal, 2012; pp. 227–245.
  3. S.S. Hickson, et al., 2010: 10.1016/j.jcmg.2010.09.016
  4. Reference Values for Arterial Stiffness’ Collaboration, 2010: 10.1093/eurheartj/ehq165
  5. C. Vlachopoulos, et al., 2010: 10.1016/j.jacc.2009.10.061
  6. Y. Ben-Shlomo, et al., 2014: 10.1016/j.jacc.2013.09.063
  7. P.M. Nilsson, et al., 2009: 10.1161/HYPERTENSIONAHA.109.129114
  8. N.R. Gaddum, et al., 2013: 10.1007/s10439-013-0854-y
  9. H. Obeid, et al., 2017: 10.1097/HJH.0000000000001371
  10. G.S. Reusz, et al., 2020: 10.1016/j.atherosclerosis.2020.04.026
  11. J. Alastruey, 2011: 10.1016/j.jbiomech.2010.12.002
  12. L.M. Van Bortel, et al., 2012: 10.1097/HJH.0b013e32834fa8b0
  13. S. Laurent, et al., 2006: 10.1093/eurheartj/ehl254
  14. M. Willemet, et al., 2015: 10.1152/ajpheart.00175.2015
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